over active bladder problems

You have little to lose by cutting the mirabegron back to 25 mg. Did you call the doctor? Had your husband tried any other medication before this? And has he had a recent culture and sensitivity test of his urine? Infection is the most common reason for sudden changes in bladder function and it is at least possible that infection set in about the time he upped the dosage. Meanwhile, I suggest he investigate condom catheters. In many ways it is your least intrusive option.

Check this thread:

inspiredsciforum.com/thread/3314/bladder-issue-label-defect

As an alternative to medication, has your husband's urologist suggested bladder botox? I had my first injection almost a year ago, and have been able to sleep through the night since, and don't worry at all about frequency. It's a great alternative for an overactive bladder. It's literally changed my life.

It is a simple, outpatient procedure, and involves about 10 injections into the bladder, using only a local anaesthetic injection first. It paralyzes the bladder, which becomes nice and quiet. Emptying is via cathing, as before the injections. The treatment is repeated every 4-6 months.

It's worth a shot! (pardon the pun)