Inspired Spinal Cord Injury Support Forum

paolo
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StemCells, Inc. First Subject in Canada Transplanted Jan 10, 2014 17:12:55 GMT -8

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Post by paolo on Jan 10, 2014 17:12:55 GMT -8

"First Subject in Canada Transplanted at the University of Calgary

NEWARK, Calif., Jan. 10, 2014 (GLOBE NEWSWIRE) -- StemCells, Inc. (Nasdaq:STEM) announced today that a team at the University of Calgary successfully transplanted its first subject in the Company's Phase I/II clinical trial in chronic spinal cord injury, with the Company's proprietary HuCNS-SC® human neural stem cells. The ninth subject to enroll in the trial, which was initiated in Switzerland...."

investor.stemcellsinc.com/phoenix.zhtml?c=86230&p=irol-newsArticle&ID=1889773&highlight=

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StemCells, Inc. First Subject in Canada Transplanted Jan 11, 2014 1:59:22 GMT -8

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Post by Lαrα on Jan 11, 2014 1:59:22 GMT -8

This is a great development in Canada....

"With this transplantation in Canada, we have the first international trial investigating neural stem cells for spinal cord injury," said Stephen Huhn, M.D., FACS, FAAP, Vice President, CNS Clinical Research at StemCells, Inc. "The 12-month data from the first cohort has demonstrated a favorable safety profile, and sensory gains first detected in two of the three subjects at the six-month assessment have persisted. The third subject remains stable. We are extremely encouraged with the progress of our spinal cord injury program and the transition into an international study will accelerate completion of enrollment."
(extract taken from the linked article provided by @poalo)

DJ
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StemCells, Inc. First Subject in Canada Transplanted Jan 11, 2014 6:38:06 GMT -8

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Post by DJ on Jan 11, 2014 6:38:06 GMT -8

Thanks for sharing paolo! I was actually going to post about this today but I'm glad you got to it first

This is definitely something big as far a spinal cord injury research goes and I'd love to see what happens with this in the future!

rob New Member Posts: 7 Post Likes Received: 4 Date Joined: January 2014 Injury: T9 - L1 Date Injured: May 21 1998 Member is: Offline Send PM	StemCells, Inc. First Subject in Canada Transplanted Jan 13, 2014 9:12:59 GMT -8 Quote Select Post Deselect Post Link to Post Back to Top Post by rob on Jan 13, 2014 9:12:59 GMT -8 excellent news .. we'll have to track this research project closely.
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iloveellisse Junior Member Posts: 99 Post Likes Received: 48 Date Joined: August 2013 Injury: T10 Incomplete Date Injured: 16-09-2012 Member is: Offline Send PM	StemCells, Inc. First Subject in Canada Transplanted Jan 13, 2014 9:38:03 GMT -8 Quote Select Post Deselect Post Link to Post Back to Top Post by iloveellisse on Jan 13, 2014 9:38:03 GMT -8 This is really good news guys, maybe the cure is not so far away!
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mikeb New Member Posts: 31 Post Likes Received: 42 Date Joined: October 2013 Injury: c6 Date Injured: 1985 Member is: Offline Send PM	StemCells, Inc. First Subject in Canada Transplanted Jan 13, 2014 12:03:17 GMT -8 Quote Select Post Deselect Post Link to Post Back to Top Post by mikeb on Jan 13, 2014 12:03:17 GMT -8 there seems to be a wave of promising technologies. i'm excited.
	DJ, kilg0retr0ut, and 1 more like this "from the top of the mountain, you can not see the mountain."

kilg0retr0ut Advanced Member Posts: 2,507 Post Likes Received: 1,862 Date Joined: July 2013 Injury: L4/5 Cauda Equina Date Injured: 7-15-10 Member is: Offline Send PM	StemCells, Inc. First Subject in Canada Transplanted Jan 13, 2014 14:29:01 GMT -8 Quote Select Post Deselect Post Link to Post Back to Top Post by kilg0retr0ut on Jan 13, 2014 14:29:01 GMT -8 I agree mikeb and Welcome Seems like it's so close.
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freewheeler Senior Member Posts: 258 Post Likes Received: 119 Date Joined: July 2013 Injury: T10 Date Injured: Dec 2012 Member is: Offline Send PM	StemCells, Inc. First Subject in Canada Transplanted Jan 13, 2014 23:56:08 GMT -8 Quote Select Post Deselect Post Link to Post Back to Top Post by freewheeler on Jan 13, 2014 23:56:08 GMT -8 Sounds very promising paolo
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paolo
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StemCells, Inc. First Subject in Canada Transplanted Jan 14, 2014 7:46:20 GMT -8

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Post by paolo on Jan 14, 2014 7:46:20 GMT -8

Jan 13, 2014 23:56:08 GMT -8 freewheeler said:

Sounds very promising paolo

Yes it is promising as in the first cohorth of pathients (3 patients treated with T Injury ASIA A) two of them have recovered few levels of sensation and it has been documented with electrophysiology one year after the treatment.
In a few months data from the second cohort of patients (Asia B patients) should be reported. The ongoing recruting is for ASIA C patients and they paln to finish recruting soon:
"We are confident that we will wrap up enrollment in Q1 2014, which should pave the way for the controlled Phase II efficacy trial that we plan to initiate in the middle of 2014."
seekingalpha.com/article/1939261-stemcells-ceo-writes-letter-to-shareholders-identifies-upcoming-catalysts?source=email_rt_article_readmore

The animal studies on which the trial is based, showed significant recovery in incomplete SCI, so this is not a cure, but hopefully it willl be an effective therapy for some people with SCI (more likely for the incomplete SCI)
That would bring excitement & money in the field and accelerate progress toward more effective therapies for all.. I hope!

Paolo

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kilg0retr0ut Advanced Member Posts: 2,507 Post Likes Received: 1,862 Date Joined: July 2013 Injury: L4/5 Cauda Equina Date Injured: 7-15-10 Member is: Offline Send PM	StemCells, Inc. First Subject in Canada Transplanted Jan 14, 2014 8:11:33 GMT -8 Quote Select Post Deselect Post Link to Post Back to Top Post by kilg0retr0ut on Jan 14, 2014 8:11:33 GMT -8 Buy,Buy,Buy Time to reactivate the Etrade. Thanks again Paolo, I really enjoy reading your posts.
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DJ Administrator STAFF Posts: 8,162 Post Likes Received: 2,829 Date Joined: July 2013 Injury: C6 - ASIA B Date Injured: June 2011 Member is: Offline Send PM	StemCells, Inc. First Subject in Canada Transplanted Jan 14, 2014 8:32:17 GMT -8 Quote Select Post Deselect Post Link to Post Back to Top Post by DJ on Jan 14, 2014 8:32:17 GMT -8 That's great paolo! I like how they mention that it's not a cure but will be like effective therapy and not give people false hope
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paolo
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StemCells, Inc. First Subject in Canada Transplanted Jan 14, 2014 9:25:49 GMT -8

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Post by paolo on Jan 14, 2014 9:25:49 GMT -8

Jan 14, 2014 8:32:17 GMT -8 DJ said:

That's great paolo! I like how they mention that it's not a cure but will be like effective therapy and not give people false hope

Here it was just me pointing out it's not a cure for the reason you mention, but I can tell you for sure they have been very carefull in running the trial and reporting results not to be accused of giving false hope.
In other cases I have seen press releses written in a misleading way to hype the results probably to drive money in a specific direction

Paolo

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DJ
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StemCells, Inc. First Subject in Canada Transplanted Jan 14, 2014 11:38:47 GMT -8

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Post by DJ on Jan 14, 2014 11:38:47 GMT -8

Jan 14, 2014 9:25:49 GMT -8 paolo said:

Jan 14, 2014 8:32:17 GMT -8 DJ said:

That's great paolo! I like how they mention that it's not a cure but will be like effective therapy and not give people false hope

Here it was just me pointing out it's not a cure for the reason you mention, but I can tell you for sure they have been very carefull in running the trial and reporting results not to be accused of giving false hope.
In other cases I have seen press releses written in a misleading way to hype the results probably to drive money in a specific direction

Paolo

I hear you paolo, it makes a change!

bob Member Posts: 156 Post Likes Received: 55 Date Joined: December 2013 Injury: Father to son with t12 Date Injured: Jan 1998 Member is: Offline Send PM	StemCells, Inc. First Subject in Canada Transplanted Jan 15, 2014 19:31:38 GMT -8 Quote Select Post Deselect Post Link to Post Back to Top Post by bob on Jan 15, 2014 19:31:38 GMT -8 Sam Maddox the CDRF research blogger just did a piece on StemCells in an article titled stem cell trials updates
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StemCells, Inc. First Subject in Canada Transplanted Jan 19, 2014 12:11:23 GMT -8

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Post by delboy on Jan 19, 2014 12:11:23 GMT -8

Good news to hear
I personally have an affinity with stem cell inc since i was invited to Switzerland to be assessed as a potential candidate. I can confirm that for the week i stayed at Bulgrist University paraplegic hospital in Zurich all accommodation, travel, meals and flights for two persons, myself and a guest was all paid for by stem cell inc. The Swiss gov medical authorities had made stem cell inc sign a 17 page protocol all designed to safe guard my interests. As for other trials in other countries i cannot comment however on this i can confirm the Swiss have extremely high medical ethical standards.

After one week of intensive tests an infected sore had excluded my candidacy. I found the study team extremely professional especially Profs Armin Curt who was head of the clinical trial. I had the opportunity to discuss the outcomes of the trial. Once the safety barrier has been proven scientifically more experimentation with scaffolds nogo inhibitors and cell dose will follow for more effective results. This i am eager to to see ie. the elusive proof and by this i mean scientific proof of efficacy on a massive scale.

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StemCells, Inc. First Subject in Canada Transplanted

Post by paolo on Jan 10, 2014 17:12:55 GMT -8

Post by Lαrα on Jan 11, 2014 1:59:22 GMT -8

Post by DJ on Jan 11, 2014 6:38:06 GMT -8

Post by rob on Jan 13, 2014 9:12:59 GMT -8

Post by iloveellisse on Jan 13, 2014 9:38:03 GMT -8

Post by mikeb on Jan 13, 2014 12:03:17 GMT -8

Post by kilg0retr0ut on Jan 13, 2014 14:29:01 GMT -8

Post by freewheeler on Jan 13, 2014 23:56:08 GMT -8

Post by paolo on Jan 14, 2014 7:46:20 GMT -8

Post by kilg0retr0ut on Jan 14, 2014 8:11:33 GMT -8

Post by DJ on Jan 14, 2014 8:32:17 GMT -8

Post by paolo on Jan 14, 2014 9:25:49 GMT -8

Post by DJ on Jan 14, 2014 11:38:47 GMT -8

Post by bob on Jan 15, 2014 19:31:38 GMT -8

Post by delboy on Jan 19, 2014 12:11:23 GMT -8

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