Hope for Breathing Issues in Cervical Injuries
Apr 15, 2015 1:43:25 GMT -8
Post by Lαrα on Apr 15, 2015 1:43:25 GMT -8
Research on rats has proven to be successful in improving breathing function of injured rats.
Dr Pippa Warren is carrying out a study of breathing recovery in high-level and chronic spinal cord injuries at Case Western Reserve University in Ohio. In November she reported that breathing function could be fully restored in animals with high-level injury using the enzyme chondroitinase,
This gives hope to those who suffer similarly with high level Spinal Cord Injury where their breathing function is affected this research has the potential to give the chance of recovery.
Pippa’s study gives laboratory rats with spinal cord injury a mixture of air with a lower concentration of oxygen for short periods of time on most days. This doesn’t involve any effort for the rats and they usually just go to sleep. While they are sleeping the low oxygen level causes them to breathe more deeply, and it is this deep breathing combined with the breakdown of the injury scar by chondroitinase that appears to enable nerves to reconnect, strengthen any spared connections and allow natural breathing to be restored.
The combination of the two treatments boosts serotonin levels around the injury site and stimulates the nerve cells. Serotonin, a neurotransmitter, is naturally produced by the body and is widely known for its role in maintaining mood and reducing anxiety and depression. In this study it has helped to reconnect nerves and reverse the paralysis of the diaphragm.
The combination of the two treatments boosts serotonin levels around the injury site and stimulates the nerve cells. Serotonin, a neurotransmitter, is naturally produced by the body and is widely known for its role in maintaining mood and reducing anxiety and depression. In this study it has helped to reconnect nerves and reverse the paralysis of the diaphragm.
Not only was the combined treatment successful in most cases but it even worked for animals with long-term injuries. Her study included some rats with injuries up to 18 months old, close to the animal’s natural lifespan.
Pippa said “One rat had had diaphragm paralysis for 18 months – it had been injured for 70% of its life. This is equivalent to being injured when it was a teenager, and receiving a treatment when it was about 70 years old. I gave it a treatment and, amazingly, it worked.
“We were thrilled by the results. Chondroitinase on its own had very modest effects on diaphragm function immediately after trauma, but we hypothesised that it would work better in chronic injuries. In acute cases, shortly after injury, the scar is still being made, but in chronic injuries the scar is complete. If we can break down the scar with chondroitinase at this stage it won’t be renewed. This is incredibly positive news for people with long-standing injuries.”
Pippa said “One rat had had diaphragm paralysis for 18 months – it had been injured for 70% of its life. This is equivalent to being injured when it was a teenager, and receiving a treatment when it was about 70 years old. I gave it a treatment and, amazingly, it worked.
“We were thrilled by the results. Chondroitinase on its own had very modest effects on diaphragm function immediately after trauma, but we hypothesised that it would work better in chronic injuries. In acute cases, shortly after injury, the scar is still being made, but in chronic injuries the scar is complete. If we can break down the scar with chondroitinase at this stage it won’t be renewed. This is incredibly positive news for people with long-standing injuries.”
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