In a new study the PhD students Jan Hoeber, Niclas König and Carl Trolle, working in Dr.Elena Kozlova's research group transplanted human stem cells to an avulsion injury in mice with the aim to restore a functional route for sensory information from peripheral tissues into the spinal cord. The results show that the transplanted stem cells act as a "bridge" which allows injured sensory nerve fibers to grow into the spinal cord, rebuild functional nerve connections, and thereby achieve long term restoration of major parts of the lost sensory functions. The transplanted stem cells differentiated to different types of cells with variable level of maturation, specific for the nervous system. No signs of tumor development or any functional abnormalities from the transplants were observed in the study, outcomes which are important in view of potential risks with transplantation of embryonic stem cells.
This is great but I get disappointed when I hear human trials will take another five to ten years. We all want to be mice and rats. I know safety is a major concern and I agree but if they prove safety lets get it to human trials asap. I know I would sign up. I get involved with many research trials and feel their great. Sometimes they prove things that where never thought of like Harkemers electrical stimulation implants. they were looking to attack pain and found nerves responding. Looking forward to hear more goods news from her.
I agree joemonte, all these lab testings but no human testing. That's why I'm really optimistic about the Epidural Stimulation treatment because it had been proven to work on humans!
Recovery in sensory nerves has intrigued me for many years. The younger ones on the forum probably know little or nothing about polio. The outbreak in the US was worst in the late 40's and early 50's. People with polio, even those with the highest level of physical disability, retained sensation. How did this happen? Why were nerves that control activity destroyed or impaired, but those that control sensation remain intact? I have many friends who contracted polio when they were infants or grammar school age. In general their quality of life and longevity were superior to those with SCI.
Sparing of sensory nerves would be an obvious boon to bowel, bladder, and sexual function. It would also help with preventing decubiti. Many of us experience weird feelings when something is wrong, but we can't pinpoint the problem. Sensation would help with diagnosing those issues. For paraplegics it could be argued that complete return of sensation might be more important than limited recovery of mobility. For quadriplegics it would be more important to regain use of the upper extremities and hands, IMO.
hobo I've heard of polio but don't know too much about it. That's an interesting observation you've made. I am a C6 ASIA B quadriplegic meaning that I have no movement below my injury but some sensation. The sensation that I do have is far from normal but it's certainly better than nothing and I'm glad I have it.
I agree with your last paragraph and I think most people with spinal cord injuries would agree as well.