I thought this type of treatment was pretty doable and would be a great start to further developments. I would like to hear any updates in layman's terms
Good to see you back jawaid I will attempt to explain it to you, i just hope my understanding translates to something that makes sense lol
Ok..the presentation is being given by Dr Jerry Silver at the Case Western Reserve University..he starts by explaining that for higher level injured individuals the function they most want back is the function to breath without the need for a vent.
The development is that he and his team have succesfully been able to restore breathing in an animal model by using an old and new technique to bridge a lesion in the spinal cord.
The old technique being nerve graft to help restore function, up until now nerve grafting has not been succesful in a spinal cord. The reason it seems is that after injury scar tissue develops, the scar tissue contains properties that prevents nerve growth.
The new technique then deals with this problem within the scar tissue. A bacterial enzyme injected into the area gets rid of the scar tissue so the combined technique is this: A nerve graft (which is the old technique) bridges that gap that is caused by the lesion/injury, then the enzyme in injected into the starting points on the graft where it adjoins the peripheral nerve (the peripheral nerve runs along the spinal cord from the brain and nerves branch off to limbs and organs.)
This injected removes the scar tissue that has been preventing nerve re growth so now it is removed, the gap is bridged the nerves are able to reconnect and restore good breathing function.
If anyone has a better understanding or way to describe then please chip in...i just hope my explanation is clear to understand and i have got it right lol
The only things I could clarify is that Chondroitinase ABC is injected at both ends of the graft. (Not the graft itself since this is known to tear up and damage the graft).
Multiple grafts are inserted at the lesion site. It's an old method for sure and used by Henrich Cheng in Taiwan on patients yet today.
The peptide injections are short chain amino acids that are given under the skin each day. It doesn't remove or breakdown the scar per se like the Chondroitinase ABC does, but it causes the growing axons coming from the astrocytes within the bridge to ignore the CSPG (scar). The peptide is causing an unusual growth of fibers or regeneration within the 5HT system.
After the breathing model was proven with a hemi-section to one lung, Dr. Silver moved on and did a transection model also in his next cohort of animals to restore bladder function and it worked again.
In his latest 2013 presentation in the U2FP library, you'll see the results on what happened to locomotion on acute animal injuries. He's working on chronic animals as he explains at the end of this presentation. You can see the presentation by following the instructions on the main page u2fp.org/