Every two years the International Symposium on Neural Regeneration takes place at the Asilomar Conference Center in Pacific Grove California. As a mother and advocate for the spinal cord injured throughout the world since 2005, I decided this would be the year I would venture into the science world and discover more about the inner workings of how academia reports, collaborates and acknowledges its work in the field of neural regeneration. Seldom does a layman register for such an intense science conference normally attended by scientists, senior researchers and post doc students to observe. After following the progression of research and clinical trials for spinal cord injury after my own son’s spinal injury, I was compelled to attend this renowned working conference on regeneration to get a sense of where the field really is. The world has waited for decades for a treatment or therapy to help recovery from paralysis.
grammy,i am presently reading through the report that you have linked to and thought i would comment as i go along...
The first point i picked up on was your thoughts on the students and how they could potentially, be playing a more significant part in nerve regeneration.
Indeed, they will have very inquiring minds and it seems a shame that finances or protocol is affecting their potential.
You also talk of the motivation behind the students when working on research and how they would work with that degree of passion of they knew fully how individuals were devastatingly effected by Spinal Cord Injury in their every day lives. This makes great sense to me because it would give them an intrinsic motivation. They would work at making progress not just for the acclaim and outward rewards but a personal one also knowing the difference in people's lives their work could lead to.
I can also see the importance of another point that was raised and this was regarding using human patients instead of rodents. I know this has had some discussion on the forum but only touched on it to be honest. Progress, I agree, can be furthered if we could see outcomes that are evident in individuals with SCI.
Thankyou for sharing the report with us grammy and well done for the good work you are doing
I wish I could have listed all of the projects being worked on but there were so many. I'll report on a few more of them in the coming months, especially the ones already showing remarkable return of function in humans. It really was a fantastic opportunity to attend, but near impossible to cover 3 full days into just one report.
I wish I could have listed all of the projects being worked on but there were so many. I'll report on a few more of them in the coming months, especially the ones already showing remarkable return of function in humans. It really was a fantastic opportunity to attend, but near impossible to cover 3 full days into just one report.
Are you sure there currently is good evidence showing "Remarkable Recovery" of function in humans? source please
Grass roots advocacy fertilized by Big Pharma-DICHOTOMY at it's best
I wish I could have listed all of the projects being worked on but there were so many. I'll report on a few more of them in the coming months, especially the ones already showing remarkable return of function in humans. It really was a fantastic opportunity to attend, but near impossible to cover 3 full days into just one report.
Are you sure there currently is good evidence showing "Remarkable Recovery" of function in humans? source please
I think in all fairness to grammy, we should wait for future reports to be available before jumping to conclusions or discussing a point when there, is nothing to read yet bob.
Currently there is no treatment so this would be big news
But anyway
I think in all fairness to grammy, we should wait for future reports to be available before jumping to conclusions or discussing a point when there, is nothing to read yet bob
Every two years the International Symposium on Neural Regeneration takes place at the Asilomar Conference Center in Pacific Grove California. As a mother and advocate for the spinal cord injured throughout the world since 2005, I decided this would be the year I would venture into the science world and discover more about the inner workings of how academia reports, collaborates and acknowledges its work in the field of neural regeneration. Seldom does a layman register for such an intense science conference normally attended by scientists, senior researchers and post doc students to observe. After following the progression of research and clinical trials for spinal cord injury after my own son’s spinal injury, I was compelled to attend this renowned working conference on regeneration to get a sense of where the field really is. The world has waited for decades for a treatment or therapy to help recovery from paralysis.
thanks for attending the meeting and for writing a report.
I would like to ask you a clarification on this that you wrote:
So is the holy grail really cortical-spinal tract regeneration? If meaningful function can be elicited from other tracts regenerating that would bring about recovery, has the field set the bar too high with regeneration for those suffering and awaiting a therapy these past decades? My conclusion was an absolute yes, coming from the community perspective. If we wait for decades, who really benefits from a holy grail? It is time to move on with meaningful advancements.
Which are the "other tracts regenerating" you refer at?
My understanding is that in the animal models used by Dr. Courtine the injury affects the corticospinal track and then he uses epidural stimulation & drugs to induce plasticity in the injury site to partially reconnect the brain with the lower part of the spinal cord and hopefully get permanent recovery of functions.
thanks for attending the meeting and for writing a report.
Which are the "other tracts regenerating" you refer at?
Paolo
You're welcomed Paolo. It was my pleasure to attend to listen in and then write about some of things I saw and heard in the discussions.
You're correct Paolo, CSP modulation doesn't cause regeneration but rather it's harnessing plasticity of the cord. In two of the presentations given at the conference concerning neuroprosthetic technologies to restore locomotion and neuromodulation strategies for neuromuscular recovery after spinal cord injury, a large discussion took place during the question and answer period among the scientists. Is regeneration of the cortico really the holy grail that we have to wait for decades for? One scientist posed that question to the group because he's showing regeneration in his particular work with sprouting of fibers in the 5HT system and getting BBB scores of up to 18.5 out of 21 on acute animals. So, he posed the important question for the other regeneration scientists to really think about this since he's not detecting anything happening in the cortico with his work but rather in the raphe. The response of the scientists working specifically on neuroprosthetic and neuromodulations were asked which of the various spinal tracts may be important to regenerate for meaningful recovery to occur? Their choice was possibly going after the Reticulo-spinal and the Raphe-spinal. A scientist working on getting recovery of function via regeneration for chronic has told me he would vote for coeruleo-spinal and proprio-spinal, but that Vestibulo-spinal is important too. It appeared to me that Cortico (CST) came in dead last in this segment of the discussions taking place during the Q & A. It really was a fascinating segment to observe!
Great. Making your point and being nasty was of utmost importance to everyone rather than allowing discussions with the community to unfold concerning remarkable recovery of function in humans.
Here are just some of the pieces of the intricate discussions that took place among these principal investigators that were at this conference and working together. I'll be reporting their additional discussions about this recovery in the coming months as future collaborations are cemented and data unfolds in the journals they're publishing soon.